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Alapren (Enalapril)
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Alapren

Alapren is a prodrug of an ACE inhibitor used to treat hypertension and congestive heart failure. It is indicated for the management of essential or renovascular hypertension. It is indicated as monotherapy or in combination with other antihypertensive agents, such as thiazide diuretics, for an additive effect.

Other names for this medication:
Amprace, Atens, Auspril, Baripril, Cetampril, Cinbenon, Corprilor, Ditensil, Docenala, Enacodan, Enalafel, Enalaprilmaleat, Enaldun, Enaprotec, Fabotensil, Glioten, Herten, Hiperson, Hipertin, Innozide, Istopril, Nacor, Nalabest, Pulsol, Revinbace, Vexopril

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Also known as: Enalapril

Description

Alapren (enalapril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Alapren is used to treat high blood pressure (hypertension) in adults and children who are at least 1 month old.

Alapren is also used to treat congestive heart failure in adults.

Alapren is also used to treat a disorder of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart). This disorder can decrease the heart's ability to pump blood to the body.

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day Maintenance dose: 10 to 40 mg orally per day as a single dose or in 2 divided doses Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 20 mg daily in 2 divided doses Maximum dose: 40 mg orally per day in 2 divided doses Comments: -Treatment is usually combined with diuretics and digitalis. -Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 2.5 mg orally twice a day Maintenance dose: 20 mg orally per day in 2 divided doses Comments: -After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour. -If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

Usual Pediatric Dose for Hypertension:

Children 1 month to 17 years: Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response. Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients. Comment: -Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min, as no data are available.

Detailed Alapren dosage information

Overdose

If you overdose Alapren and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Alapren overdosage: fainting, dizziness.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alapren are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

No information is available on the relationship of age to the effects of enalaprilat in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving enalaprilat .

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We report a female patient with cytomegalovirus (CMV) terminal ileitis and CMV viraemia, associated with a metastatic goblet cell carcinoid (GCC) tumour of the appendix. After verification of ductal clearance, the CBD could be closed primarily without T-tube insertion. Additionally, other animal models of heart failure (eg, pressure overload, volume overload, and paced tachycardia) continue to provide important information. Recovery of calf muscle strength following acute achilles tendon rupture treatment: a comparison between minimally invasive surgery and conservative treatment. Here we evaluate the role played by the BMP agonist/antagonist axis in monocyte recruitment during atherogenesis. We report here a study on the phosphorylation of Streptococcus salivarius HPr, HPr(H15D), HPr(H15E), and HPr(His approximately P) by HprK/P to assess the involvement of HprK/P in the synthesis of HPr-P2 in streptococcal cells. Contrast-enhanced TDI is an original new tool that provides a quantification of the mean velocity of LAA-SEC that might improve our decision making in patients with atrial fibrillation. Estrogen Receptor (ERalpha) is a member of superfamily of ligand-activated transcription factors which play critical roles in many biological processes.

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