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Dulex (Duloxetine)

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Dulex is a type of antidepressant known as a serotonin–norepinephrine reuptake inhibitor used to treat depression and anxiety. Dulex may improve your mood, sleep, appetite, and energy level, and decrease nervousness.

Other names for this medication:
Ariclaim, Combac, Delok, Deneurone, Detine, Dimorex, Dulane, Dulex, Dulife, Dulojoy, Dulok, Dulonix, Dulot, Dulotin, Duloxee, Duloxetine, Duloxit, Duloxyl, Dulti, Dumore, Dutin, Duxet, Duzela, Nudep, Sylonex, Symbal, Ulozet, Verlox, Xeristar, Yentreve

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Also known as: Duloxetine


Generic Dulex is developed by medical scientists to treat major depressive disorder and general anxiety disorder. It is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors. Generic Dulex affects chemicals in the brain that may become unbalanced and cause depression. Generic Dulex is also used to treat a chronic pain disorder called fibromyalgia, treat pain caused by nerve damage in people with diabetes (diabetic neuropathy) and to treat chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain.


Usual Adult Dose for Depression:

Initial dose: 20 mg to 30 mg orally 2 times a day Maintenance dose: 60 mg per day, given either once a day OR 30 mg orally 2 times a day Maximum dose: 120 mg/day.

Usual Adult Dose for Fibromyalgia:

Initial dose: 30 mg orally once a day for at least 1 week Maintenance dose: 30 to 60 mg orally once a day.

Usual Adult Dose for Generalized Anxiety Disorder:

Initial dose: 60 mg orally once a day Maintenance dose: 60 to 120 mg orally once a day Maximum dose: 120 mg/day.

Usual Adult Dose for Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Adult Dose for Neuropathic Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Adult Dose for Chronic Pain:

Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60 mg orally once a day.

Usual Geriatric Dose for Generalized Anxiety Disorder:

Initial dose: 30 mg orally once a day for at least 2 weeks Maintenance dose: 60 mg orally once a day Maximum dose: 120 mg/day.

Usual Pediatric Dose for Generalized Anxiety Disorder:

7 to 17 years: -Initial dose: 30 mg orally once a day for at least 2 weeks -Maintenance dose: 30 to 60 mg orally once a day -Maximum dose: 120 mg/day.

Usual Pediatric Dose for Fibromyalgia:

13 years and older: -Initial dose: 30 mg orally once a day for at least 1 week -Maintenance dose: 30 to 60 mg orally once a day.

Detailed Dulex dosage information


If you overdose Generic Dulex and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Dulex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Dulex if you are allergic to Duloxetine, other SNRIs or to any of the medication's components. Do not take Dulex if you have taken recreational drugs such as ecstasy (MDMA), ketamine, LSD, poppers (amyl nitrate), narcotics or benzodiazepines. Do not take Dulex if you are taking other medications, including erythromycin, alpha-blockers, antifungal medications (ketoconazole and itraconazole), medications for HIV (ritonavir, saquinavir, nelfinavir and atazanavir), certain antibiotics (telithromycin), alprazolam (Xanax), anticoagulants (warfarin), antidepressants (Elavil, Asendin, Anafranil, Norpramin), MAOI antidepressants (Marplan, Nardil, Eldepryl, Emsam, Zelapar), SSRI antidepressants (fluvoxamine), herbal remedy St. John’s Wort, NSAIDs (Advil, Motrin, Aleve, Naprosyn), clopidogrel (Plavix), diazepam (Valium), digoxin (Lanoxin), diuretics ('water pills'), linezolid, flecainide (Tambocor), medications for diabetes, lithium (Eskalith, Lithobid), medications for anxiety and Parkinson's disease, methylene blue, medications for mental illness (Clozaril, Haldol), medications for migraine (Axert, Relpax, Frova, Amerge), medications for seizures (Tegretol, Dilantin), sedatives, sibutramine (Meridia), sleeping pills, tramadol (Ultram), tranquilizers, and vinblastine (Velban). Do not take Dulex if you experience seizures (convulsions or fits). Do not take Dulex if you suffer from or have history of cardiovascular disease, liver or kidney disorders, hypotension, leukemia, peptic ulcer disease, rhinitis, glaucoma, epilepsy. Do not take Dulex if you have a history of fainting, mania (feeling overexcited, irritable or not being able to think clearly) or severe depression. Do not take Dulex if you have recently undergone a surgery. Do not to consume alcohol, drive or operate machinery while using Dulex, as it can lower your blood pressure, causing dizziness, drowsiness. Dulex is not for use in patients under age 18 years.

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Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome. Sulfasalazine commonly used in IBD, potentially has severe adverse effects, including infertility, pulmonary fibrosis, lack of response, and ultimately patients may require intestinal resection. The persons living with schizophrenia who were interviewed for this project expressed interesting perspectives and preferences regarding ethically important aspects of recruitment, consent, and debriefing in clinical research that may help guide efforts to make research processes more attuned to participants and merit further inquiry. Intestinal protein loss in chronic arterial insufficiency of the celiac mesenteric region in aged patients. CHD was classified by type, complexity, and presence or absence of extracardiac anomalies. Our study suggests that the combination of praziquantel and albendazole sulphoxide could potentially improve the current neurocysticercosis treatment. This article delineates parallel frameworks that grew out of the research on risk and resilience over the past four decades, a framework for research and a framework for practice, and then discusses the promise of an emerging synthesis. A myelopoiesis gene signature during remission in anti-neutrophil cytoplasm antibody-associated vasculitis does not predict relapses but seems to reflect ongoing prednisolone therapy. Curcumin activated glycogen synthase kinase (GSK)-3beta, a downstream target of Akt kinase, by inhibiting phosphorylation of this protein. Treatment of the test animals with mexidol (25 mg/kg) decreases the cytolysis of hepatocytes, the development of cholestasis, the degree of hepatocellular insufficiency, the growth of endogenous intoxication, the drop of calcium content, the growth of iron content in the blood serum, and the content of final LPO products.

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Chronic hepatitis C in patients with persistently normal alanine transaminase levels. There were three infections (two superficial and one deep) in the group who received antibiotics (105 patients), 10 infections (two superficial and eight deep) in the control group (89 patients). A novel cellulolytic, anaerobic, and thermophilic bacterium, Moorella sp. Third, there was no significant difference in the visual acquisition between nurse bees, guard bees, and foragers. Primary epithelioid angiosarcoma of the lung presenting as pulmonary hemorrhage. There was no detectable increase in mutagenic activity in the urine concentrates of three pharmacy administrators who had no contact with these drugs.

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She had already undergone 3 previous muscle biopsies without definite diagnosis. Here, we demonstrate that the inactive X-chromosome in Eed(-/-) trophoblast stem cells and in cells of the trophectoderm-derived extra-embryonic ectoderm in Eed(-/-) embryos remain transcriptionally silent, despite lacking the PcG-mediated histone modifications that normally characterize the facultative heterochromatin of the inactive X-chromosome. Pediatric orbital cellulitis without sinusitis: report of four cases. Should patients with benign prostatic hypertrophy stop taking doxazosin in the light of the ALLHAT study?. Structure, function and biology of tissue factor pathway inhibitor-2. Specifically, we discuss the two illumination options for the test: point source with a grating or flat-panel display, and we discuss the tradeoffs of the two approaches. micro- and macroangiopathies) aggravated, the HDLP level, modified by LP heptanophil products, was growing up in the blood serum. A variety of agents have been used to improve cough effectiveness and prevent infectious exacerbations in patients with bronchiectasis, with variable results. The confluence of population genetics with molecular pharmacology at the angiotensin II receptor: dawn of a new era or just a new wrinkle?.

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Kinetics of uptake of lysine and lysyl-lysine by hamster jejunum in vitro. The learning traditions in nursing, including the traditional organization of professional educational curricula with an emphasis on general education, could be contributing to this discontinuity. Second, the low molecular weight signal from energy-absorbing molecules was minimized by covalently linking the energy-absorbing molecules to the backbone of the polymer and other ionization-enhancing pendant groups on the backbone. This species has a relatively compact mitochondrial genome (15,218 bp). The purpose of this study was to compare kicking biomechanics between young female soccer players at two different stages of physical maturation and to identify biomechanical predictors of peak foot velocity. The physician Hans Reiter as prisoner of war in Nuremberg: a contextual review of his interrogations (1945-1947). In the present study, we investigated whether a histone deacetylase sirtuin 1 (SIRT1) can regulate the protein stability of homeodomain-interacting protein kinase 2 (HIPK2). The formation of the metal complexes was monitored by means of X-ray photoelectron spectroscopy (XPS), which reveals that this metalation reaction leads to a chemical equivalence of all four nitrogen atoms.

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Expression of the specific type IV phosphodiesterase gene PDE4B3 during different phases of long-term potentiation in single hippocampal slices of rats in vitro. Such washing is laborious, lengthens assay time, and increases assay scatter. Intraoral mucosa lesion in secondary syphilis: report of 4 cases. We found that external ATP is required for maintenance of the import competence of mitochondrial precursor proteins but that, once they bind to mitochondria, the subsequent translocation of presequence-containing proteins, but not the ADP/ATP carrier, proceeds independently of external ATP. A multivariate analysis of correlates of life satisfaction in adulthood.

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The variables are factored into a series of realizable functions and most constants were determined from the dynamic constants for the tetanic contraction of frog ventricular muscle at 20 degrees C. Incubation of gut and protozoa extracts with class-specific protease inhibitors revealed that most of the proteases were serine proteases. Tooth malpositions and the cross-bite relationship between maxilla and mandible could play a major role in promoting these events. These experiments show that the anterograde transport of HRP can be used to distinguish differences in the morphology of separate populations of severed axons. Radiation Therapy Oncology Group 0848 will ultimately determine whether erlotinib produces a survival benefit in patients with resected pancreatic cancer. Resistances are of considerable significance in psychoterapy with adolescents.

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However, although a large number of GAST and CCK-related sequences have been identified both in vertebrate and non-vertebrate species, the evolutionary history of the GAST/CCK family remains little understood. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with how much does differin cost in canada LIM domains. Moreover it is suggested that the low activity of cathepsin B1 may be related to the low rate of cell protein catabolism characteristic of the developing liver (Conde and Scornik, 1977). Our study identifies a large number of problems in the quality of our radiology requisitions. Magnetic resonance imaging findings and histopathological observations after percutaneous renal cryoablation in the rabbit model. A comparative study of the influence of some protecting groups on the reactivity of D-glucosamine acceptors with a galactofuranosyl donor. Third molar mineralisation appeared identical in both control and experimental specimens indicating that they were not sensitive to the influence of direct maternal control since lactation at the time of mineralisation was being superceded by general food sources. The high metastatic sublines secreted higher levels of activated matrix metalloprotease (MMP)-9 as well as pro-MMP-9 in the culture medium than the parent lines. Social role interventions may improve health and well-being for people in retirement transition.

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An epidemiological study of registered cases positive for atypical mycobacteria in the tuberculosis surveillance system. Other myelopathy causes in HIV/AIDS include opportunistic infections, neoplasms, vascular lesions and metabolic disease. A total of 162 patients with intracranial glioblastoma multiforme or gliosarcomas who had undergone surgery and radiotherapy participated in this multicenter, double-blind, placebo-controlled, parallel group study conducted at 20 institutions. Increase in serum vecuronium concentration following sugammadex administration in a pediatric patient after prolonged sedation. The S-isotopic analysis of DMS is difficult due to its low concentrations in natural seawater biaxin liquid dosage and high chemical reactivity. Eight Florida counties have a significantly pronounced black-white infant mortality gap: Broward, Duval, Gadsden, Hillsborough, Miami-Dade, Orange, Palm Beach, and Putnam.

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Long-term surveillance is essential in all cases of lymphomatoid papulosis as accurate predictors for the development of malignant lymphoma in these individuals are still lacking. Aiming to see if the questionnaire was a useful tool in picking up high-risk individuals. Prismatic magnetite magnetosomes from cultivated Magnetovibrio blakemorei strain MV-1: a magnetic fingerprint in marine sediments?. Furthermore, increased hsps in primary breast cancers correlates with resistance to therapy and decreased survival. The amplitude of the Achilles tendon reflex in infants is related to body position. Bile acids and their sulphated and glucuronidated derivatives in bile, plasma, and urine of children with intrahepatic cholestasis: effects of phenobarbital treatment. The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis. Microbial populations stimulated for hexavalent uranium reduction in uranium mine sediment.

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Our recent findings demonstrated that NgBR binds farnesylated Ras and recruits Ras to the plasma membrane, which is a critical step required for the activation of Ras signaling in human breast cancer cells and tumorigenesis. Together, our data suggest that AMACO represents a member of the Fraser complex. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. These data do not support the hypothesis that the less favorable review outcomes for clinical applications are related to these review factors. Evaluation of the inhibitory potential of five squaric acid derivatives against pancreatic lipase. Automobile airbags have been universally installed to save lives in motor vehicle accidents, but have also been linked with facial and thoracic burns and chest trauma during rapid deployment.

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The importance of NoVs as a major gastrointestinal pathogen underscores the need for well tolerated and effective vaccines. No differences were found between the PMNC frequencies of the negative control and the 30 and 50 mg/kg MTZ groups. Hitherto, ECC studies with grass pollen are conducted primarily outside of the pollen season to avoid the influence of natural pollen exposure. There remains a risk of late reintervention following either form of repair. Finally, surgical or genetic elimination of retinal input greatly accelerated the rate of corticogeniculate innervation, with axons invading between P2 and P3 and fully innervating dLGN by P8 to P10. A statistical survey of Canadian forensic mental health inpatient programs.

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To determine if the skills to successfully ventilate using the laryngeal mask (The Laryngeal Mask Company Limited, Henley on Thames, United Kingdom) and Combitube (The Kendall Company, Mansfield, USA) can be retained after seven months. Review of these three cases and 13 cases previously reported suggests that retained appendiceal barium may be significant when it exists in either of two patterns. We report the case of a 60-year-old man who presented with a two day history of headache, altered sensorium and left hemiplegia. Community structure of zoohydrobionts in the lake affected by chemical weapon destruction was studied for the first time. When these antibodies were saturated with cell-wall-derived glycopeptides in order to abolish the binding to carbohydrate side chains, they still recognized the same cell-wall polypeptides as did the untreated antibodies. Autoradiographic quantification of the local cerebral blood flow, calculated according to the microsphere model, produced identical results for both molecules. The human PTH receptor type 2 (PTH2R) is activated by PTH what happens if i miss a dose of wellbutrin xl and tuberoinfundibular peptide of 39 residues (TIP39), resulting in cAMP and intracellular Ca signaling. After pre-operative administration of 1 g, latamoxef disodium (moxalactam) levels were measured in peripheral venous blood, skeletal muscle and subcutaneous fat sampled from 29 patients during either arterial reconstruction or amputation undertaken for arterial occlusive disease. We studied the acute toxicity of MCA before clinical symptoms appeared in fasting rats. Seven-tesla magnetic resonance imaging in Wilson disease using quantitative susceptibility mapping for measurement of copper accumulation.

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