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Sofosbuvir

Sofosbuvir is a prescription medicine used with other antiviral medicines to treat adults with chronic (lasting a long time) hepatitis C virus (HCV): genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis in combination with peginterferon alfa and Sofosbuvir.

Other names for this medication:
Sofosbuvir

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Provera, Inderal, Zebeta, Precose, Coumadin, Alprostadil, Neurontin, Sovaldi, Miambutol, Hycoril, Novazole, Linezonix, Cutimom, Glimsite,

Description

Sofosbuvir (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) from multiplying in your body.

Sofosbuvir is used to treat chronic hepatitis C in adults and children who are at least 3 years old.

Sofosbuvir must be given in combination with other antiviral medications (usually ribavirin with or without peginterferon alfa). It should not be used alone.

Sofosbuvir treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Sofosbuvir is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 1 or 4: Sofosbuvir, peginterferon alfa, and ribavirin for 12 weeks -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Genotype 1, 4: This regimen is recommended for therapy-naive patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Genotype 2, 3: Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The dose recommendations for genotype 1, 2, 3, or 4 should be followed for HCV/HIV-1-coinfected patients. -The manufacturer product information should be consulted for ribavirin tablet dose recommendations; with genotype 1 or 4, the manufacturer product information for peginterferon alfa should also be consulted for dose recommendations. -Sofosbuvir and ribavirin for 24 weeks can be considered for patients with genotype 1 infection who cannot use an interferon-based regimen; treatment decision should be guided by benefit/risk assessment for the individual patient. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: As a part of a combination antiviral treatment regimen, for the treatment of chronic HCV infection -In combination with pegylated interferon and ribavirin: For genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis -In combination with ribavirin: For genotype 2 or 3 infection without cirrhosis or with compensated cirrhosis

Usual Pediatric Dose for Chronic Hepatitis C:

3 years or older: -Weight less than 17 kg: 150 mg orally once a day -Weight 17 to less than 35 kg: 200 mg orally once a day -Weight at least 35 kg: 400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The manufacturer product information should be consulted for ribavirin dose recommendations. -The same dose recommendations should be followed for HCV/HIV-1-coinfected patients. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: In combination with ribavirin, for the treatment of chronic HCV genotype 2 or 3 infection in patients without cirrhosis or with compensated cirrhosis

Detailed Sofosbuvir dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 to 86 degrees F) away from moisture and heat. Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sofosbuvir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Sofosbuvir if you are allergic to sofosbuvir. When taking Sofosbuvir with other medicine: To make sure all medicines are safe for you, tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

To make sure Sofosbuvir is safe for you, tell your doctor if you have ever had:

hepatitis B (you may be tested for this before you take sofosbuvir); a liver transplant; liver problems other than hepatitis C; kidney disease (or if you are on dialysis); HIV or AIDS; a heart rhythm problem for which you take a medicine called amiodarone; or if you use a blood thinner (warfarin, Coumadin, Jantoven) and you have routine "INR" or prothrombin time tests.

Sofosbuvir is sometimes used in combination with ribavirin. Both men and women using ribavirin should use effective birth control to prevent pregnancy. Ribavirin can cause birth defects, miscarriage, or death to an unborn baby if the mother or father is using this medicine.

You should not take ribavirin if you are pregnant, or if you are a man and your sex partner is pregnant. Use effective birth control to prevent pregnancy. Keep using birth control for at least 6 months after your last dose of ribavirin.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ribavirin.

It may not be safe to breastfeed while using Sofosbuvir. Ask your doctor about any risk.

Sofosbuvir is not approved for use by anyone younger than 3 years old.

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COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer. They induce electrophile-responsive element (EpRE)-mediated expression of enzymes, such as NAD(P)H-quinone oxidoreductase (NQO1) and glutathione S-transferases (GSTs), which are major defense enzymes against electrophilic toxicants and oxidative stress. An NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.6.99.2) was purified from Glycine max seedlings by means of chromatographic procedures. Intravitreal gas injection for macular hole with localized retinal detachment in highly myopic patients. State of synapses of the cortex of cerebral hemispheres on gamma-irradiation. Complex plastids of euglenids and chlorarachneans bounded by three and four membranes, respectively, most likely arose via two separate secondary endosymbioses of a green alga in a eukaryotic host. Pure sensory stroke due to midbrain haemorrhage limited to the spinothalamic pathway. Occupational health nurses should evaluate employee satisfaction with and expectations of occupational health services offered.

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The conditions of tear film formation and stability are governed by the surface chemical characteristics of the tear film system and by the proper functioning of the lacrimal apparatus. Characterization of the appressorium cDNA library and identification of genes overrepresented early in P. Finally, altered endothelial cells may contract and expose basement membrane to blood, thus enhancing thrombosis. Understanding the interactions physicians have with vaccine-hesitant parents, as well as the opinions physicians hold regarding vaccination, exemption, and exemption policies, are critical to our understanding of, and ability to affect, vaccination exemption rates among children. Maturation of in vitro-generated human islets after transplantation in nude mice. However, in patients with acute cholecystitis, the role of this technique remains controversial and some clinicians regard this condition as a contraindication to laparoscopic cholecystectomy. Recently, researchers have accumulated a large amount of time-course transcriptome data collected under different treatment conditions to understand the physiological states of cells in response to extracellular stimuli and to identify drug-responsive genes. CARCINOMA OF THE LUNG: THE CHANGING PATTERN OF MORTALITY IN ONTARIO. Platelet-rich plasma in combination with bovine derived xenograft in the treatment of deep intrabony periodontal defects: a report of 20 consecutively treated patients.

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