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Xafenor (Fenofibrate)
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Xafenor

Xafenor is a fibric acid derivative like clofibrate and gemfibrozil. Xafenor is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia. Xafenor was granted FDA approval on 31 December 1993.

Other names for this medication:
Catalip, Craveril, Fegenor, Fenobrate, Fenocap, Fenofib, Fenofibratum, Fenogal, Fenohexal, Fenox, Fibral, Fulcro, Hafenthyl, Lexemin, Lifen, Lipcor, Lipilfen, Lipofene, Lipohexal, Lowlip, Minuslip, Nubrex, Nuozhituo, Proctofene, Secalip, Stanlip, Tilene, Xafenor

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Also known as: Fenofibrate

Description

Xafenor (fenofibrate) belongs to a group of drugs known as "fibrates." It helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Xafenor is used along with a proper diet to help to treat high cholesterol and high triglyceride levels.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help Xafenor work better include exercising, losing weight if overweight, and stopping smoking.

Dosage

Usual Adult Dose of Xafenor for Hyperlipoproteinemia Type IIa (Elevated LDL): 145 mg orally once a day.

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL): 145 mg orally once a day.

Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL): 48 to 145 mg orally once a day. Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL): 48 to 145 mg orally once a day. Usual Geriatric Dose of Xafenor for Hyperlipoproteinemia: 48 mg orally once a day. Increases in dosage should occur only after evaluating the effects on renal function and lipid levels at this dose, with a maximum recommended dose of 145 mg/24 hours.

Detailed Xafenor dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Xafenor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Xafenor if you are allergic to fenofibrate, or if you have:

severe kidney disease (or if you are on dialysis); liver disease; or gallbladder disease.

Do not breast-feed while using this medicine, and for at least 5 days after your last dose.

To make sure Xafenor is safe for you, tell your doctor if you have ever had:

kidney disease; liver disease; or gallbladder problems.

Fenofibrate can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease, diabetes, or poorly controlled hypothyroidism (underactive thyroid).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Xafenor is not approved for use by anyone younger than 18 years old.

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Oxidative stress plays an important role in the pathogenesis of asthma. The effect of proxy voice intervention on couple softening in the context of enactments. Here we show that mice lacking MyD88 exhibit a dramatic reduction in proinflammatory cytokines after intravenous injection of a high dose of HDAd, and show significantly reduced induction of the adaptive immune response when compared with wild-type and TLR2-deficient mice. Functional outcomes were evaluated with the visual analog scale score, modified Mayo Elbow Performance Score, and Disabilities of the Arm, Shoulder and Hand score. This relationship was concentrated in meningioma cases and may represent a marker for an elevated socioeconomic status.

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